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DNA poly-ADP ribosylation

The risky business of ADP-ribosylating telomeric DNA

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ADP-ribosylation regulates the activity of numerous proteins involved in the DNA damage response and repair. A new study shows that telomeric DNA can be ADP-ribosylated by PARP1, and prompt removal of the ADP-ribose by TARG1 is essential to preserve telomere integrity, unveiling DNA–ADP-ribosylation as a novel player in telomere stability.

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Fig. 1: Proposed model for ADP-ribosylation of telomeric DNA.

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Acknowledgements

F.L. is a Wallenberg Molecular Medicine fellow and receives financial support from the Knut and Alice Wallenberg Foundation (KAW), CancerFonden and Vetenskapsrådet.

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Correspondence to Ylli Doksani or Francisca Lottersberger.

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Doksani, Y., Lottersberger, F. The risky business of ADP-ribosylating telomeric DNA. Nat Struct Mol Biol 31, 737–738 (2024). https://doi.org/10.1038/s41594-024-01285-8

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