Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau filaments identical to those found in individuals with sporadic or dominantly inherited Alzheimer disease (AD), but also two types of Aβ40 filaments with distinct structures different from those previously reported in AD and cerebral amyloid angiopathy.
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This is a summary of: Fernandez, A. et al. Cryo-EM structures of amyloid-β and tau filaments in Down syndrome. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01252-3 (2024).
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High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01254-1
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DOI: https://doi.org/10.1038/s41594-024-01254-1
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