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Ubiquitin in autophagy and non-protein ubiquitination

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In addition to its role in proteasomal degradation, ubiquitin has multiple roles in autophagy. It can mark proteins for autophagic degradation and actively drive autophagosome formation. Recent work shows that ubiquitin can also be conjugated to phospholipids and other biomolecules.

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Fig. 1: Ubiquitin in autophagy induction and cargo recognition.
Fig. 2: Ubiquitination of non-protein substrates.

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Acknowledgements

The author thanks J. Sakamaki and H. Yamamoto for their helpful comments. This work was supported by a grant for Exploratory Research for Advanced Technology from the Japan Science and Technology Agency (JPMJER1702) and a Grant-in-Aid for Specially Promoted Research from the Japan Society for the Promotion of Science (22H04919).

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  1. Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Noboru Mizushima

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  1. Noboru Mizushima
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Mizushima, N. Ubiquitin in autophagy and non-protein ubiquitination. Nat Struct Mol Biol 31, 208–209 (2024). https://doi.org/10.1038/s41594-024-01217-6

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