The modification of proteins with the small protein ubiquitin constitutes a Daedalian system of posttranslational modifications in every eukaryotic cell, which is often referred to as the ubiquitin code1. Here we consider the scale and complexity of the ubiquitin system in light of recent developments.
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References
Swatek, K. N. & Komander, D. Cell Res. 26, 399–422 (2016).
Pao, K.-C. et al. Nature 556, 381–385 (2018).
Kelsall, I. R., Zhang, J., Knebel, A., Arthur, J. S. C. & Cohen, P. Proc. Natl Acad. Sci. USA 116, 13293–13298 (2019).
McCrory, E. H., Akimov, V., Cohen, P. & Blagoev, B. Biochem. J. 479, 2419–2431 (2022).
Otten, E. G. et al. Nature 594, 111–116 (2021).
Sakamaki, J. et al. Mol. Cell 82, 3677–3692.e11 (2022).
Kelsall, I. R. et al. EMBO J 41, e109700 (2022).
Zhu, K. et al. Sci. Adv. 8, eadd4253 (2022).
Sugihara, M. et al. J. Cell Biol. 218, 949–960 (2019).
Yang, C.-S. et al. Mol. Cell 66, 503–516.e5 (2017).
Zhu, K. et al. Nucleic Acids Res. 52, 801–815 (2024).
Purser, N. et al. Biochem. J. 480, 1817–1831 (2023).
Wang, X. S. et al. Nat. Commun. 14, 168 (2023).
Swatek, K. N. et al. Nature 572, 533–537 (2019).
Akimov, V. et al. Nat. Struct. Mol. Biol. 25, 631–640 (2018).
Acknowledgements
B.C.L. and D.K. are supported by National Health and Medical Research Council Investigator grants GNT2016268 (B.C.L) and GNT1178122 (D.K.).
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D.K. is a co-founder, shareholder, and scientific advisory board member of Entact Bio.
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Lechtenberg, B.C., Komander, D. Just how big is the ubiquitin system?. Nat Struct Mol Biol 31, 210–213 (2024). https://doi.org/10.1038/s41594-023-01208-z
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DOI: https://doi.org/10.1038/s41594-023-01208-z
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