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AGO2 localizes to the nucleus in quiescence and represses transposon expression

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An Ago2HA/HA mouse model combined with super-resolution microscopy, molecular and biochemical assays allowed us to stringently characterize AGO2 regulation in vivo. We found that in quiescent splenocytes, AGO2 localizes almost exclusively to the nucleus, where it binds to the RNA of young mobile transposons and represses their expression through its catalytic domain.

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Fig. 1: AGO2 localizes to the nucleus and associates with transposon transcripts in quiescent splenocytes.

References

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This is a summary of: Sala, L. et al. AGO2 silences mobile transposons in the nucleus of quiescent cells. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01151-z (2023).

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AGO2 localizes to the nucleus in quiescence and represses transposon expression. Nat Struct Mol Biol 30, 1838–1839 (2023). https://doi.org/10.1038/s41594-023-01169-3

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