OAT1 has a fundamental role in the kidney by facilitating the urinary excretion of various drugs and endogenous metabolites. Two studies now present high-resolution structures of OAT1 using cryo-EM, elucidating its intricate polyspecific transport capabilities and paving the way for structure-based drug research and development.
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The author acknowledges the NIH (R01GM138675) for funding his research work.
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Chang, L. OAT1 structures reveal insights into drug transport in the kidney. Nat Struct Mol Biol 30, 1615–1617 (2023). https://doi.org/10.1038/s41594-023-01144-y
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DOI: https://doi.org/10.1038/s41594-023-01144-y
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