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Telomere stability

All roads lead to MRN regulation at telomeres: different paths to one solution

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New work shows that in mammals, the iDDR motif of telomere factor TRF2 inhibits the MRE11–RAD50–NBS1 (MRN) complex at chromosome ends through a direct iDDR–RAD50 interaction. Unrelated protein motifs in yeasts inhibit MRN functions via an analogous mechanism, suggesting a convergent evolution in eukaryotes to control MRN action at telomeres.

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Fig. 1: RAD50-interacting motifs inhibit MRN-initiated resection at telomeres.

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Acknowledgements

We thank S. Gruber, M. Houmel, H. W. Liu and S. Castelli for critical reading of this essay. F.R.H. is supported by an EMBO postdoctoral fellowship (ATLF 302-2022). Work in S.M.’s lab is supported by grants from the ANR, FRM, ARC, CEA and LNCC.

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Authors and Affiliations

  1. Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne (UNIL), Lausanne, Switzerland

    Florian Roisné-Hamelin

  2. Université Paris-Saclay, Université Paris-Cité, Inserm, CEA, Institut de Biologie François Jacob, iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France

    Stéphane Marcand

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  1. Florian Roisné-Hamelin
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  2. Stéphane Marcand
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Correspondence to Stéphane Marcand.

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Roisné-Hamelin, F., Marcand, S. All roads lead to MRN regulation at telomeres: different paths to one solution. Nat Struct Mol Biol 30, 1242–1243 (2023). https://doi.org/10.1038/s41594-023-01077-6

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