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Single-cell joint analysis of gene expression and histone modifications in droplets

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Here we report Droplet Paired-Tag, a rapid and robust method to simultaneously profile histone modifications and gene expression in single cells at scale. The new procedure provides researchers with a tool for studying the epigenome and gene regulation in complex tissues and disease pathogenesis.

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Fig. 1: Droplet Paired-Tag reveals multiple cell types in the mouse brain.

References

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This is a summary of: Xie, Y. et al. Droplet-based single-cell joint profiling of histone modifications and transcriptomes. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01060-1 (2023).

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Single-cell joint analysis of gene expression and histone modifications in droplets. Nat Struct Mol Biol 30, 1407–1408 (2023). https://doi.org/10.1038/s41594-023-01076-7

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