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DNA replication stress

Replication licensing during S phase: breaking the law to prevent breaking DNA

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A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading during S phase, risking genotoxic over-replication. But can this rule be broken in emergency situations to preserve genome integrity?

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Fig. 1: Different consequences of weak and strong checkpoint activation during DNA replication of very long genes.

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Acknowledgements

I thank B. Kerem for critical reading of this essay. The work in my lab most relevant to this study is funded by US National Institues of Health grant R01CA270335.

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Authors and Affiliations

  1. Laboratory of Chromosome Replication and Epigenome Regulation, San Diego Biomedical Research Institute, San Diego, CA, USA

    David M. Gilbert

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  1. David M. Gilbert
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Correspondence to David M. Gilbert.

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Gilbert, D.M. Replication licensing during S phase: breaking the law to prevent breaking DNA. Nat Struct Mol Biol 30, 406–408 (2023). https://doi.org/10.1038/s41594-023-00962-4

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