The RNA methyltransferase (MTase) METTL1 catalyzes N7-methylguanosine (m7G) modification at position 46 in human transfer RNAs (tRNAs). Its dysregulation drives tumorigenesis in many cancer types. Two papers now reveal the structural basis of this tRNA maturation event.
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The authors acknowledge support from the CNRS, the Agence Nationale de la Recherche (ANR-19-CE07-0028 and ANR-19-CE44-0013) and the LabEx DYNAMO (ANR-11-LABX-0011).
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Barraud, P., Tisné, C. Cracking the case of m7G modification in human tRNAs. Nat Struct Mol Biol 30, 242–243 (2023). https://doi.org/10.1038/s41594-023-00937-5
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DOI: https://doi.org/10.1038/s41594-023-00937-5
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