An elegant cryo-EM and biophysical study unveils the conformational changes of the E. coli MutS mismatch repair factor. This provides a nice follow-up to the recent report from the same group characterizing how MutS scans DNA without initiating repair on correctly base-paired DNA and recruits MutL upon encountering a mismatch.
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J.B.C. thanks the French National Research Agency for support (ANR-20-CE11-0026, ANR-17-CE12-0020 and ANR- 18-CE44-0008).
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Charbonnier, J.B. Tandem regulation of MutS activity by ATP and DNA during MMR initiation. Nat Struct Mol Biol 29, 5–7 (2022). https://doi.org/10.1038/s41594-021-00713-3
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DOI: https://doi.org/10.1038/s41594-021-00713-3
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