Skip to main content
Log in

AlphaFold2 and the future of structural biology

  • Correspondence
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Jumper, J. et al. Nature https://doi.org/10.1038/s41586-021-03819-2 (2021).

  2. Tunyasuvunakool, K. et al. Nature https://doi.org/10.1038/s41586-021-03828-1 (2021).

  3. Steinegger, M. et al. BMC Bioinformatics 20, 473 (2019).

    Article  Google Scholar 

  4. Pereira, J. et al. Proteins https://doi.org/10.1002/prot.26171 (2021).

  5. AlQuraishi, M. Bioinformatics 35, 4862–4865 (2019).

    Article  CAS  Google Scholar 

  6. Baek, M. et al. Science https://doi.org/10.1126/science.abj8754 (2021).

  7. Berman, H. M. Nat. Struct. Mol. Biol. 28, 400–401 (2021).

    Article  CAS  Google Scholar 

  8. Walzthoeni, T., Leitner, A., Stengel, F. & Aebersold, R. Curr. Opin. Struct. Biol. 23, 252–260 (2013).

    Article  CAS  Google Scholar 

  9. Rossmann, M. G. Acta Crystallogr. D Biol. Crystallogr. 57, 1360–1366 (2001).

    Article  CAS  Google Scholar 

  10. Cramer, P. Cell 182, 787–789 (2020).

    Article  CAS  Google Scholar 

  11. Masarati, G. et al. J. Mol. Biol. https://doi.org/10.1016/j.jmb.2021.167127 (2021).

  12. Xu, Y. et al. J. Chem. Inf. Model. 60, 2773–2790 (2020).

    Article  CAS  Google Scholar 

  13. Borcherds, W., Bremer, A., Borgia, M. B. & Mittag, T. Curr. Opin. Struct. Biol. 67, 41–50 (2021).

    Article  CAS  Google Scholar 

  14. Turk, M. & Baumeister, W. FEBS Lett. 594, 3243–3261 (2020).

    Article  CAS  Google Scholar 

  15. Tegunov, D., Xue, L., Dienemann, C., Cramer, P. & Mahamid, J. Nat. Methods 18, 186–193 (2021).

    Article  CAS  Google Scholar 

  16. O’Reilly, F. J. et al. Science 369, 554–557 (2020).

    Article  Google Scholar 

  17. Bykov, Y. S., Cortese, M., Briggs, J. A. & Bartenschlager, R. FEBS Lett. 590, 1877–1895 (2016).

    Article  CAS  Google Scholar 

  18. Holmes, K. C. Endeavour 33, 60–66 (1974).

    CAS  PubMed  Google Scholar 

  19. Hendrickson, W. A., Horton, J. R. & LeMaster, D. M. EMBO J. 9, 1665–1672 (1990).

    Article  CAS  Google Scholar 

  20. McMullan, G., Faruqi, A. R. & Henderson, R. Methods Enzymol. 579, 1–17 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

I thank S. Dodonova, J. Söding and D. Tegunov for comments.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Patrick Cramer.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cramer, P. AlphaFold2 and the future of structural biology. Nat Struct Mol Biol 28, 704–705 (2021). https://doi.org/10.1038/s41594-021-00650-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-021-00650-1

  • Springer Nature America, Inc.

This article is cited by

Navigation