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N-END RULE

Degradation of proteins with N-terminal glycine

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The ‘N-end rule’ correlates the identity of the N-terminal residue of a protein to its in vivo half-life. A study has now shown that an N-terminal glycine can serve as a potent degradation signal, which reveals a novel branch of N terminus–dependent protein degradation.

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Fig. 1: The discovery of N-terminal glycine degron pathway and its functional ramifications.

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Author notes

  1. Mohamed Eldeeb

    Present address: McGill Parkinson Program, Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

    Mohamed Eldeeb

  2. Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

    Mansoore Esmaili & Richard Fahlman

  3. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada

    Richard Fahlman

Authors
  1. Mohamed Eldeeb
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  2. Mansoore Esmaili
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  3. Richard Fahlman
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Corresponding author

Correspondence to Mohamed Eldeeb.

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The authors declare no competing interests.

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Eldeeb, M., Esmaili, M. & Fahlman, R. Degradation of proteins with N-terminal glycine. Nat Struct Mol Biol 26, 761–763 (2019). https://doi.org/10.1038/s41594-019-0291-1

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