The study of the female brain during pregnancy and motherhood is gaining traction, and holds the potential to address the unmet needs of millions of women worldwide. Here we highlight the most pressing gaps in this field. Filling these knowledge gaps will require two paths forward: focused longitudinal studies that deeply characterize individuals, and collaborative initiatives that build large-scale international databases.
References
Jacobs, E. G. Nature 623, 667 (2023).
Servin-Barthet, C. et al. Nat. Rev. Neurosci. 24, 605–619 (2023).
Hoekzema, E. et al. Nat. Neurosci. 20, 287–296 (2017).
Hoekzema, E. et al. Nat. Commun. 13, 6931 (2022).
Paternina-Die, M. et al. Nat. Neurosci. 27, 319–327 (2024).
Pritschet, L., Taylor, C. M., Santander, T. & Jacobs, E. G. Curr. Opin. Behav. Sci. 40, 72–78 (2021).
Barth, C. & de Lange, A. G. Front. Neuroendocrinol. 58, 100850 (2020).
Ye, C. et al. Nat. Nanotechnol. 19, 330–337 (2024).
Levin, G. & Ein-Dor, T. Transl. Psychiatry 13, 138 (2023).
Pritschet, L. et al. Preprint at bioRxiv https://doi.org/10.1101/2023.12.14.571688 (2023).
Marek, S. et al. Nature 603, 654–660 (2022).
Orchard, E. R., Rutherford, H. J. V., Holmes, A. J. & Jamadar, S. D. Trends Cogn. Sci. 27, 302–316 (2023).
de Lange, A. G. et al. Proc. Natl. Acad. Sci. USA 116, 22341–22346 (2019).
Heller, C. et al. Nature Mental Health https://doi.org/10.1038/s44220-024-00224-2 (2024).
Barth, C., Crestol, A., de Lange, A. G. & Galea, L. A. M. Lancet Diabetes Endocrinol. 11, 926–941 (2023).
Acknowledgements
M.M.-G and E.G.J are supported by The Ann S. Bowers Women’s Brain Health Initiative. A.-M.G.d.L. is supported by the Swiss National Science Foundation (PZ00P3_193658). S.C. is supported by a Miguel Servet Type II research contract (CPII21/00016), and co-funded by the European Social Fund ‘Investing in your future’.
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Martínez-García, M., Jacobs, E.G., de Lange, AM.G. et al. Advancing the neuroscience of human pregnancy. Nat Neurosci 27, 805–807 (2024). https://doi.org/10.1038/s41593-024-01629-z
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DOI: https://doi.org/10.1038/s41593-024-01629-z
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