Neuroscientists have long believed that hunger increases activity in agouti-related peptide (AgRP) neurons to regulate feeding-related behaviors and metabolism, but a new study shows that the story is much more complicated. Sayar-Atasoy and colleagues show that the time of day uncouples activity in AgRP neurons from hunger and demonstrate how daily feeding patterns influence future AgRP neuron activity.
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Andrews, Z.B. Daily feeding entrains hunger-sensing neurons. Nat Neurosci 27, 10–12 (2024). https://doi.org/10.1038/s41593-023-01508-z
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DOI: https://doi.org/10.1038/s41593-023-01508-z
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