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Neuroimmunology

Navigating T cell brain entry in MS

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is driven by autoreactive lymphocytes. An in vivo CRISPR screen of T cell infiltration in a rat model of MS now identifies the genetic modules that control this key step in the immunopathology of MS.

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Fig. 1: Identifying the molecular mechanisms that regulate CD4 T cell migration to the CNS during MS.

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Authors and Affiliations

  1. Department of Pathology, University of Cambridge, Cambridge, UK

    Magda Ali & Adrian Liston

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  1. Magda Ali
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  2. Adrian Liston
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Correspondence to Adrian Liston.

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The authors declare no competing interests.

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Ali, M., Liston, A. Navigating T cell brain entry in MS. Nat Neurosci 26, 1661–1662 (2023). https://doi.org/10.1038/s41593-023-01433-1

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