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Social behavior

Control of social hierarchy beyond neurons

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Noh et al. show that the regulation of social behavior extends beyond neurons. Astrocytes, a major type of glial cell in the CNS, can influence social dominance behavior by modulating excitatory and inhibitory neural activities in the dorsomedial prefrontal cortex of adult male mice. This work highlights the importance of neuron–astrocyte interplay in controlling ethologically relevant behaviors.

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Fig. 1: Astrocytes in the dmPFC modulate social rank and dominance in male mice through bidirectional modulation of synaptic excitatory/inhibitory balance.

References

  1. Zhou, T., Sandi, C. & Hu, H. Curr. Opin. Neurobiol. 49, 99–107 (2018).

    Article  CAS  PubMed  Google Scholar 

  2. Chen, P. & Hong, W. Neuron 98, 16–30 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Wang, F. et al. Science 334, 693–697 (2011).

    Article  CAS  PubMed  Google Scholar 

  4. Zhang, C. et al. Neuron 110, 516–531.e6 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Kingsbury, L. et al. Cell 178, 429–446.e16 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Padilla-Coreano, N. et al. Nature 603, 667–671 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Noh, K. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01406-4 (2023).

    Article  PubMed  Google Scholar 

  8. Lyon, K. A. & Allen, N. J. Front. Neural Circuits 15, 136 (2022).

    Article  Google Scholar 

  9. Khakh, B. S. & Deneen, B. Annu. Rev. Neurosci. 42, 187–207 (2019).

    Article  CAS  PubMed  Google Scholar 

  10. Bazargani, N. & Attwell, D. Nat. Neurosci. 19, 182–189 (2016).

    Article  CAS  PubMed  Google Scholar 

  11. Yu, X. et al. Neuron 108, 1146–1162.e10 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Bicks, L. K., Koike, H., Akbarian, S. & Morishita, H. Front. Psychol. 6, 1805 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Martin-Fernandez, M. et al. Nat. Neurosci. 20, 1540–1548 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Adamsky, A. et al. Cell 174, 59–71.e14 (2018).

    Article  CAS  PubMed  Google Scholar 

  15. Yu, X. et al. Neuron 99, 1170–1187.e9 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Nguyen T. Phi & Weizhe Hong

  2. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Nguyen T. Phi & Weizhe Hong

  3. Department of Molecular and Integrative Physiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA

    Xinzhu Yu

Authors
  1. Nguyen T. Phi
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  2. Xinzhu Yu
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  3. Weizhe Hong
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Correspondence to Weizhe Hong.

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Phi, N.T., Yu, X. & Hong, W. Control of social hierarchy beyond neurons. Nat Neurosci 26, 1485–1486 (2023). https://doi.org/10.1038/s41593-023-01392-7

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