We found reduced N6-methyladenosine (m6A) RNA modification in neurons differentiated from induced pluripotent stem cells from patients with amyotrophic lateral sclerosis or frontotemporal dementia caused by C9orf72 repeat expansion. This reduction disturbs global gene expression and exacerbates neurodegeneration. Strategies to restore the m6A level hold great promise as therapeutic approaches.
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This is a summary of: Li, Y. et al. Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01374-9 (2023)
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Dysregulation of RNA methylation contributes to neurodegeneration. Nat Neurosci 26, 1322–1323 (2023). https://doi.org/10.1038/s41593-023-01389-2
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DOI: https://doi.org/10.1038/s41593-023-01389-2
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