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Alzheimer’s disease

A TREM2 antibody energizes microglia

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Loss-of-function variants of TREM2 increase risk for Alzheimer’s disease. A new study presents a therapeutic candidate — ATV:TREM2, a TREM2-activating antibody engineered with a transferrin receptor binding site to facilitate blood-to-brain transport. Treatment of a mouse model of Alzheimer’s disease with ATV:TREM2 improved energy metabolism and microglial function.

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Fig. 1: An engineered AVT:TREM2 antibody for blood-to-brain transport and targeted activation of microglia.

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Acknowledgements

N.Z. is supported by NIH/NIA grant R01AG066395.

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Authors and Affiliations

  1. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

    Na Zhao

  2. SciNeuro Pharmaceuticals, Rockville, MD, USA

    Guojun Bu

Authors
  1. Na Zhao
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  2. Guojun Bu
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Corresponding authors

Correspondence to Na Zhao or Guojun Bu.

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Competing interests

G.B. is an employee of SciNeuro Pharmaceuticals.

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Zhao, N., Bu, G. A TREM2 antibody energizes microglia. Nat Neurosci 26, 366–368 (2023). https://doi.org/10.1038/s41593-023-01265-z

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