We developed a wearable platform (the Neuro-stack) for recording single-neuron and local field potentials in freely moving humans. The Neuro-stack enabled the recording of single-neuron activity during walking behavior in humans. The platform also enables personalized stimulation during real-time decoding of neural activity, which can potentially improve neurostimulation treatments.
References
Musall, S., Kaufman, M. T., Juavinett, A. L., Gluf, S. & Churchland, A. K. Single-trial neural dynamics are dominated by richly varied movements. Nat. Neurosci. 22, 1677–1686 (2019). A paper that reports the impact of animal movement on neural activity.
Schulze-Bonhage, A. Brain stimulation as a neuromodulatory epilepsy therapy. Seizure 44, 169–175 (2012). A paper that reports the effectiveness of brain stimulation in epilepsy treatment.
Rozgic, D. et al. A 0.338 cm3, artifact-free, 64-contact neuromodulation platform for simultaneous stimulation and sensing. IEEE Trans. Biomed. Circuits Syst. 13, 38–55 (2019). A paper reporting the design of the integrated circuits that we used in our study.
Stangl, M. et al. Boundary-anchored neural mechanisms of location-encoding for self and others. Nature 589, 420–425 (2021). A paper reporting increased neural activity when in close proximity to boundaries.
Ezzyat, Y. et al. Direct brain stimulation modulates encoding states and memory performance in humans. Curr. Biol. 27, 1251–1258 (2017). A paper that reports memory enhancement after brain stimulation and machine learning decoding of the neural activity.
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This is a summary of: Topalovic, U. et al. A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01260-4 (2023)
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Recording single-neuron activity during walking in humans. Nat Neurosci 26, 377–378 (2023). https://doi.org/10.1038/s41593-023-01261-3
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DOI: https://doi.org/10.1038/s41593-023-01261-3
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