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MYELIN PLASTICITY IN LEARNING

Motor learning revamps the myelin landscape

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Learning requires new oligodendrogenesis, but how myelin patterns change during learning is unclear. Bacmeister et al. show that motor learning induces phase-specific changes in myelination on behaviorally activated axons that correlate with motor performance, suggesting myelin remodeling is involved in learning.

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Fig. 1: Using in vivo longitudinal imaging, Bacmeister et al. examined myelin sheath dynamics in primary motor cortex of mice trained to perform a seed-reaching task.

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Acknowledgements

This work was supported by the National Institutes of Health/National Institute of Neurological Disorders and Stroke/National Institute for Mental Health (grants R01NS115746 and R01MH125515 to J.R.C. and grant F32NS116214 to W.X.), the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (APND grant A130141 to J.R.C.), and the Rachleff Family Endowment.

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  1. Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, CA, USA

    Wendy Xin & Jonah R. Chan

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  1. Wendy Xin
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  2. Jonah R. Chan
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Correspondence to Wendy Xin or Jonah R. Chan.

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The authors declare no competing interests.

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Xin, W., Chan, J.R. Motor learning revamps the myelin landscape. Nat Neurosci 25, 1251–1252 (2022). https://doi.org/10.1038/s41593-022-01156-9

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