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Cortical norepinephrine GRABs a seat at the sleep table

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A new study shows that infra-slow cortical norepinephrine oscillations shape the micro-structure of sleep and transitions to micro-arousals, wakefulness or rapid eye movement (REM) sleep. Prolonged descending phases of these oscillations promote the occurrence of spindle-rich intermediate sleep, which is involved in memory consolidation.

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Fig. 1: Schematic representation of sleep architecture orchestration by NE-mediated mPFC activity.

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Acknowledgements

This work was funded by the Fyssen Foundation and an EMBO post-doctoral fellowhip (J.F.M.), an ATIP-Avenir grant, Emergence(s) Ville de Paris, a NARSAD BBRF Young Investigator Award and the FSER (Fondations Schlumberger pour la Recherche et l’Education) (G.G.).

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  1. Institut du Fer à Moulin, UMRS 1270, Inserm, Sorbonne Université, Paris, France

    Juan Facundo Morici & Gabrielle Girardeau

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  1. Juan Facundo Morici
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  2. Gabrielle Girardeau
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Correspondence to Gabrielle Girardeau.

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The authors declare no competing interests.

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Morici, J.F., Girardeau, G. Cortical norepinephrine GRABs a seat at the sleep table. Nat Neurosci 25, 978–980 (2022). https://doi.org/10.1038/s41593-022-01117-2

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