Skip to main content
SpringerLink
Log in

BRAIN DEVELOPMENT

Neurogenic–angiogenic synchrony via lactate

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

During cortical development, the generation of neurons from progenitors coincides with increasing vascularization and oxygen levels in the fetal brain and the transition from anaerobic to aerobic metabolism. Dong et al. identify lactate, a metabolite of anaerobic glycolysis, as a multifunctional regulator that coordinates synchrony of cortical neurogenesis and angiogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Lactate signaling coordinates synchrony of cortical neurogenesis and angiogenesis.

References

  1. Dong, X. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-022-01093-7 (2022).

    Article  PubMed  Google Scholar 

  2. Fame, R. M., Shannon, M. L., Chau, K. F., Head, J. P. & Lehtinen, M. K. Development 146, dev182857 (2019).

    Article  CAS  Google Scholar 

  3. Barros, L. F. Trends Neurosci. 36, 396–404 (2013).

    Article  CAS  Google Scholar 

  4. Li, A. et al. Angiogenesis 8, 63–71 (2005).

    Article  CAS  Google Scholar 

  5. Khacho, M. et al. Cell Stem Cell 19, 232–247 (2016).

    Article  CAS  Google Scholar 

  6. Vasudevan, A., Long, J. E., Crandall, J. E., Rubenstein, J. L. & Bhide, P. G. Nat. Neurosci. 11, 429–439 (2008).

    Article  CAS  Google Scholar 

  7. Keil, J. M. et al. Nat. Commun. 11, 3839 (2020).

    Article  CAS  Google Scholar 

  8. Stubbs, D. et al. Cereb. Cortex 19, i32–i41 (2009).

    Article  Google Scholar 

  9. Paredes, I., Himmels, P. & Ruiz de Almodóvar, C. Dev. Cell 45, 10–32 (2018).

    Article  CAS  Google Scholar 

  10. Swinnen, N. et al. Glia 61, 150–163 (2013).

    Article  Google Scholar 

  11. Shi, L., Qalieh, A., Lam, M. M., Keil, J. M. & Kwan, K. Y. Nat. Commun. 10, 2588 (2019).

    Article  Google Scholar 

  12. Penna, E., Mangum, J. M., Shepherd, H., Martínez-Cerdeño, V. & Noctor, S. C. Cereb. Cortex 31, 2139–2155 (2021).

    Article  Google Scholar 

  13. Doyle, D. Z. et al. Proc. Natl Acad. Sci. USA 118, e2100686118 (2021).

    Article  CAS  Google Scholar 

  14. Monsorno, K., Buckinx, A. & Paolicelli, R. C. Trends Endocrinol. Metab. 33, 186–195 (2022).

    Article  CAS  Google Scholar 

  15. Fame, R. M. & Lehtinen, M. K. Front. Cell Dev. Biol. 9, 780207 (2021).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Michigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, MI, USA

    Daniel Z. Doyle & Kenneth Y. Kwan

  2. Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA

    Daniel Z. Doyle & Kenneth Y. Kwan

  3. Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA

    Daniel Z. Doyle & Kenneth Y. Kwan

Authors
  1. Daniel Z. Doyle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenneth Y. Kwan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kenneth Y. Kwan.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Doyle, D.Z., Kwan, K.Y. Neurogenic–angiogenic synchrony via lactate. Nat Neurosci 25, 839–840 (2022). https://doi.org/10.1038/s41593-022-01111-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-022-01111-8

  • Springer Nature America, Inc.

Search

Navigation