Adult male rodents have long been known to show stronger hippocampal long-term potentiation (LTP) and learning than females. Le et al. find that this sex difference is reversed in pre-pubescent animals, and identify a female-specific mechanism that increases LTP threshold and decreases spatial memory in females after puberty.
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Tronson, N.C. Puberty reverses sex differences in learning. Nat Neurosci 25, 134–135 (2022). https://doi.org/10.1038/s41593-021-00986-3
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DOI: https://doi.org/10.1038/s41593-021-00986-3
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