Our brains are wired to steer us toward novel experiences. Ogasawara et al. define nodes in a network that underlies novelty-seeking behavior distinct from novelty-orienting responses. In this network, anterior ventral medial temporal cortex (AVMTC) mediates novelty-related sensory processing, and zona incerta uses input from AVMTC to guide gaze shifts for novelty seeking.
References
Jaegle, A., Mehrpour, V. & Rust, N. Curr. Opin. Neurobiol. 58, 167–174 (2019).
Ogasawara, T. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-021-00950-1 (2021).
Ghazizadeh, A., Griggs, W. & Hikosaka, O. Front. Neurosci. 10, 378 (2016).
Jutras, M. J. & Buffalo, E. A. Proc. Natl. Acad. Sci. USA 107, 401–406 (2010).
Lak, A., Stauffer, W. R. & Schultz, W. eLife 5, e18044 (2016).
Menegas, W., Babayan, B. M., Uchida, N. & Watabe-Uchida, M. eLife 6, e21886 (2017).
Morrens, J., Aydin, Ç., Janse van Rensburg, A., Esquivelzeta Rabell, J. & Haesler, S. Neuron 106, 142–153.e7 (2020).
Matsumoto, M. & Hikosaka, O. Nature 447, 1111–1115 (2007).
Bromberg-Martin, E. S., Matsumoto, M. & Hikosaka, O. Neuron 68, 815–834 (2010).
Tapper, A. R. & Molas, S. Neurobiol. Learn. Mem. 176, 107323 (2020).
Watabe-Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A. & Uchida, N. Neuron 74, 858–873 (2012).
Murray, E. A. & Richmond, B. J. Curr. Opin. Neurobiol. 11, 188–193 (2001).
Xiang, J. Z. & Brown, M. W. Neuropharmacology 37, 657–676 (1998).
Acknowledgements
The authors are supported by The Intramural Research Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services under report ZIAMH 002619. The opinions expressed in this article are the authors’ own and do not necessarily reflect the view of the US National Institutes of Health, the Department of Health and Human Services, or the US Government.
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Wang, W., Eldridge, M.A.G. & Richmond, B.J. Novelty seeking for novelty’s sake. Nat Neurosci 25, 7–8 (2022). https://doi.org/10.1038/s41593-021-00965-8
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DOI: https://doi.org/10.1038/s41593-021-00965-8
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