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ENTERIC NERVOUS SYSTEM

Revealing the complexity of the gut’s brain

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A new study proposes an exciting new model of neuronal diversification in the developing enteric nervous system (ENS) and establishes a detailed molecular taxonomy for enteric neurons. Their findings open new horizons for ENS research and for developing cell-based therapies for ENS disorders.

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Fig. 1: Twelve unique ENCs arise from a binary fate split during development with subsequent diversification of postmitotic neuronal populations.

References

  1. Furness, J.B. The Enteric Nervous System (Blackwell Publishing, 2006).

  2. Ganz, J., Melancon, E. & Eisen, J. S. Methods Cell Biol. 134, 139–164 (2016).

    Article  CAS  Google Scholar 

  3. Neunlist, M. et al. Nat. Rev. Gastroenterol. Hepatol. 10, 90–100 (2013).

    Article  CAS  Google Scholar 

  4. Ganz, J. Dev. Dyn. 247, 268–278 (2018).

    Article  Google Scholar 

  5. Rao, M. & Gershon, M. D. Nat. Rev. Neurosci. 19, 552–565 (2018).

    Article  CAS  Google Scholar 

  6. Morarach, K. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-020-00736-x (2020).

  7. Zeisel, A. et al. Cell 174, 999–1014.e22 (2018).

    Article  CAS  Google Scholar 

  8. Holguera, I. & Desplan, C. Science 362, 176–180 (2018).

    Article  CAS  Google Scholar 

  9. Lasrado, R. et al. Science 356, 722–726 (2017).

    Article  CAS  Google Scholar 

  10. Drokhlyansky, E. et al. Cell 182, 1606–1622.e23 (2020).

    Article  CAS  Google Scholar 

  11. May-Zhang, A.A. et al. Gastroenterology https://doi.org/10.1053/j.gastro.2020.09.032 (2020).

  12. Brosens, E. et al. Dev. Biol. 417, 198–208 (2016).

    Article  CAS  Google Scholar 

  13. Heuckeroth, R. O. Nat. Rev. Gastroenterol. Hepatol. 15, 152–167 (2018).

    Article  Google Scholar 

  14. Rao, M. & Gershon, M. D. Nat. Rev. Gastroenterol. Hepatol. 13, 517–528 (2016).

    Article  CAS  Google Scholar 

  15. Burns, A. J. et al. Dev. Biol. 417, 229–251 (2016).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Integrative Biology, Michigan State University, East Lansing, MI, USA

    Julia Ganz

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  1. Julia Ganz
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Correspondence to Julia Ganz.

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The author declares no competing interests.

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Ganz, J. Revealing the complexity of the gut’s brain. Nat Neurosci 24, 1–2 (2021). https://doi.org/10.1038/s41593-020-00769-2

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  • DOI: https://doi.org/10.1038/s41593-020-00769-2

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