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REWARD LEARNING AND BEHAVIOR

When does midbrain dopamine activity exert its effects on behavior?

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Rewards direct behavioral adaptation through midbrain dopamine signaling, though the timing of those effects is often ambiguous. Lee and colleagues find that different subpopulations of dopamine neurons obey similar constraints, indirectly regulating reward-related behavior through learning mechanisms restricted to a brief time window following reward.

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Fig. 1: Manipulation of mDA neuron activity induces learning effects within a tight temporal window following reward delivery.

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  1. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA

    Luke T. Coddington

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  1. Luke T. Coddington
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Correspondence to Luke T. Coddington.

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The author declares no competing interests.

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Coddington, L.T. When does midbrain dopamine activity exert its effects on behavior?. Nat Neurosci 23, 154–156 (2020). https://doi.org/10.1038/s41593-019-0577-y

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