In 2004, Weaver et al. published evidence in Nature Neuroscience for the lasting epigenetic impact of maternal care within the hippocampus of rat offspring. This conceptual and methodological leap contributed to the evolution of environmental and behavioral epigenetics and continues to inspire challenging questions about genes, environments, and their legacy.
References
Brenner, S., Jacob, F. & Meselson, M. Nature 190, 576–581 (1961).
Goldberg, A. D., Allis, C. D. & Bernstein, E. Cell 128, 635–638 (2007).
Liu, D. et al. Science 277, 1659–1662 (1997).
Weaver, I. C. G. et al. Nat. Neurosci. 7, 847–854 (2004).
Razin, A. & Riggs, A. D. Science 210, 604–610 (1980).
Lefebvre, L. et al. Nat. Genet. 20, 163–169 (1998).
Ridley, M. Nurture via Nature: Genes, Experience, and What Makes Us Human. (Harper Collins, New York, 2003).
Fraga, M. F. et al. Proc. Natl. Acad. Sci. USA 102, 10604–10609 (2005).
Hannon, E. et al. Genome Biol. 17, 176 (2016).
Franklin, T. B. et al. Biol. Psychiatry 68, 408–415 (2010).
Gapp, K. et al. Nat. Neurosci. 17, 667–669 (2014).
Champagne, F. A. Front. Neuroendocrinol. 29, 386–397 (2008).
Mashoodh, R., Habrylo, I. B., Gudsnuk, K. M., Pelle, G. & Champagne, F. A. Proc. R. Soc. Lond. B. https://doi.org/10.1098/rspb.2018.0118 (2018).
Laland, K. N. et al. Proc. R. Soc. Lond. B. https://doi.org/10.1098/rspb.2015.1019 (2015)..
Hellstrom, I. C., Dhir, S. K., Diorio, J. C. & Meaney, M. J. Phil. Trans. R. Soc. Lond. B 367, 2495–2510 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Champagne, F.A. Beyond the maternal epigenetic legacy. Nat Neurosci 21, 773–774 (2018). https://doi.org/10.1038/s41593-018-0157-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-018-0157-6
- Springer Nature America, Inc.
This article is cited by
-
The role of epigenetics in anxiety disorders
Molecular Biology Reports (2023)