Skip to main content
SpringerLink
Log in

ABSENCE SEIZURES

Heartless beat or beatless heart?

  • News & Views
  • Published:

From Nature Neuroscience

View current issue Submit your manuscript

Recurring bursts of thalamocortical cells were thought to be indispensable in driving absence seizures. A new study demonstrates that bursts from inhibitory thalamic reticular neurons are crucial instead. Reticular bursts are driven by cortical inputs and govern precise timing of thalamocortical cell activity during seizures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: The thalamocortical system.

Marina Corral Spence/Springer Nature

References

  1. Hüser, J., Blatter, L. A. & Lipsius, S. L. J. Physiol. (Lond.) 524, 415–422 (2000).

    Article  Google Scholar 

  2. Bohn, G. et al. FEBS Lett. 481, 73–76 (2000).

    Article  CAS  PubMed  Google Scholar 

  3. Crunelli, V. et al. Nat. Rev. Neurosci. 19, 107–118 (2018).

    Article  CAS  PubMed  Google Scholar 

  4. Swadlow, H. A. & Gusev, A. G. Nat. Neurosci. 4, 402–408 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Cheong, E. & Shin, H.-S. Physiol. Rev. 93, 961–992 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Sorokin, J. M. et al. Neuron 93, 194–210 (2017).

    Article  CAS  PubMed  Google Scholar 

  7. McCafferty, C. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-018-0130-4 (2018).

    PubMed  Google Scholar 

  8. David, F. et al. J. Neurosci. 33, 19599–19610 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Rovó, Z. et al. J. Neurosci. 34, 7137–7147 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Herd, M. B., Brown, A. R., Lambert, J. J. & Belelli, D. J. Neurosci. 33, 14850–14868 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Paz, J. T. et al. Nat. Neurosci. 14, 1167–1173 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lee, S. E. et al. Proc. Natl. Acad. Sci. USA 111, 11828–11833 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Beenhakker, M. P. & Huguenard, J. R. Neuron 62, 612–632 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Barthó, P. et al. Neuron 82, 1367–1379 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Guye, M. et al. Brain 129, 1917–1928 (2006).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Thalamus Research, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

    László Acsády

Authors
  1. László Acsády
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to László Acsády.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Acsády, L. Heartless beat or beatless heart?. Nat Neurosci 21, 649–651 (2018). https://doi.org/10.1038/s41593-018-0140-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41593-018-0140-2

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation