The human brain shows regional selective vulnerability to the pathology of Alzheimer’s disease. Jacobs et al. show that the protein amyloid-β promotes the spread of tau through specific components of a neural system underlying memory formation, thus leading to the prominent early symptom of amnesia.
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The author serves as a consultant to Novartis, Genentech and Bioclinica.
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Jagust, W. Following the pathway to Alzheimer’s disease. Nat Neurosci 21, 306–308 (2018). https://doi.org/10.1038/s41593-018-0085-5
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DOI: https://doi.org/10.1038/s41593-018-0085-5
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