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How developmental cell atlases inform stem cell embryo models

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In vivo developmental atlases provide a crucial reference for the new class of stem-cell-derived human embryo models, helping accelerate insights into the mechanisms of human development.

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Fig. 1: Iterating between in vivo developmental atlases and in vitro models facilitates new insights into human development.

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Acknowledgements

This publication is part of the Human Cell Atlas (http://www.humancellatlas.org/publications). M.H., A.M. and S.A.T acknowledge Wellcome Sanger core funding (Wellcome Trust Grant 220540/Z/20/A). M.H is funded by Wellcome (WT107931/Z/15/Z) and the NIHR Newcastle Biomedical Research Centre.

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Authors and Affiliations

  1. Wellcome Sanger Institute, Cambridge, UK

    Muzlifah Haniffa, Aidan Maartens & Sarah A. Teichmann

  2. Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK

    Muzlifah Haniffa

  3. Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

    Muzlifah Haniffa

  4. Theory of Condensed Matter Group, Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge, UK

    Sarah A. Teichmann

Authors
  1. Muzlifah Haniffa
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  2. Aidan Maartens
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  3. Sarah A. Teichmann
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Corresponding authors

Correspondence to Muzlifah Haniffa or Sarah A. Teichmann.

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Competing interests

S.A.T. is a scientific advisory board member of ForeSite Labs, Qiagen and Element Biosciences, and is a co-founder and equity holder of TransitionBio and EnsoCell Therapeutics. M.H. and A.M. declare no competing interests.

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Haniffa, M., Maartens, A. & Teichmann, S.A. How developmental cell atlases inform stem cell embryo models. Nat Methods 20, 1849–1851 (2023). https://doi.org/10.1038/s41592-023-02072-x

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