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Tracing developmental lineages

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I discuss how recent advancements in lineage tracing methods have enabled rare insight into the cell fate and trajectory during development.

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Fig. 1: Lineage tracing and reconstruction.

References

  1. Kretzschmar, K. & Watt, F. M. Cell 148, 33–45 (2012).

    Article  CAS  PubMed  Google Scholar 

  2. Schier, A. F. Nat. Methods 17, 17–20 (2020).

    Article  CAS  PubMed  Google Scholar 

  3. Kelley, K. W. & Pașca, S. P. Cell 185, 42–61 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Velasco, S. et al. Nature 570, 523–527 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Uzquiano, A. et al. Cell 185, 3770–3788.e27 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. He, Z. et al. Nat. Methods 19, 90–99 (2022).

    Article  PubMed  Google Scholar 

  7. McKenna, A. et al. Science 353, aaf7907 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Simeonov, K. P. et al. Cancer Cell 39, 1150–1162.e9 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Spanjaard, B. et al. Nat. Biotechnol. 36, 469–473 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Alemany, A., Florescu, M., Baron, C. S., Peterson-Maduro, J. & van Oudenaarden, A. Nature 556, 108–112 (2018).

    Article  CAS  PubMed  Google Scholar 

  11. Raj, B. et al. Nat. Biotechnol. 36, 442–450 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Bowling, S. et al. Cell 181, 1410–1422.e27 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Raj, B. et al. Neuron 108, 1058–1074.e6 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Xie, L. et al. Nat. Methods 20, 1244–1255 (2023).

    Article  CAS  PubMed  Google Scholar 

  15. Choi, J. et al. Nature 608, 98–107 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. de Medeiros, G. et al. Nat. Commun. 13, 4864 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  17. Lange, M. et al. Preprint at bioRxiv https://doi.org/10.1101/2023.03.06.531398 (2023).

  18. Heumos, L. et al. Nat. Rev. Genet. 24, 550–572 (2023).

    Article  CAS  PubMed  Google Scholar 

  19. Sur, A., Wang, Y., Capar, P., Margolin, G. & Farrell, J. A. Preprint at bioRxiv https://doi.org/10.1101/2023.03.20.533545 (2023).

  20. Fleck, J. S. et al. Nature 621, 365–372 (2023).

    Article  CAS  PubMed  Google Scholar 

  21. Qiu, C. et al. Nat. Genet. 54, 328–341 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

B.R. is supported by Perelman School of Medicine, University of Pennsylvania startup funds, NIH/NICHD R00HD098298 and NIH/NINDS DP2NS131787.

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  1. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Bushra Raj

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  1. Bushra Raj
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Correspondence to Bushra Raj.

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Raj, B. Tracing developmental lineages. Nat Methods 20, 1852–1854 (2023). https://doi.org/10.1038/s41592-023-02067-8

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