We developed fatigue-resistant hydrogel optical fibers through the controlled growth of polymeric nanocrystalline domains to enable light delivery to peripheral nerves during locomotion. The hydrogel fibers withstand locomotion strain across more than 30,000 fiber stretch cycles and enable the optogenetic inhibition of pain hypersensitivity in naturally behaving mice.
References
Deisseroth, K. Optogenetics. Nat. Methods 8, 26–29 (2011). A review article that discusses optogenetics.
Park, S. I. et al. Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nat. Biotechnol. 33, 1280–1286 (2015). A research article that presents a wireless optoelectronics device with applications outside the brain.
Lin, S. et al. Anti-fatigue-fracture hydrogels. Sci. Adv. 5, eaau8528 (2019). A research article that reports fatigue-resistant hydrogels.
Liu, X., Liu, J., Lin, S. & Zhao, X. Hydrogel machines. Mater. Today 36, 102–124 (2020). A review article that details applications of hydrogels for interfaces with biological systems.
Park, S. et al. Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity. Nat. Commun. 12, 3435 (2021). A research article that describes hydrogel-based multifunctional neural probes.
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This is a summary of: Liu, X. et al. Fatigue-resistant hydrogel optical fibers enable peripheral nerve optogenetics during locomotion. Nat. Methods https://doi.org/10.1038/s41592-023-02020-9 (2023).
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Hydrogel fibers that enable optogenetic pain inhibition during locomotion. Nat Methods 20, 1641–1642 (2023). https://doi.org/10.1038/s41592-023-02022-7
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DOI: https://doi.org/10.1038/s41592-023-02022-7
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