A new chemically induced dimerization (CID) pair exhibits fluorescence upon dimerization for the first time. Moreover, the CID pair is small and offers easily reversible dimerization that can be repeated multiple times.
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References
Benedetti, L. et al. Proc. Natl. Acad. Sci. USA 115, E2238–E2245 (2018).
Stanton, B. Z., Chory, E. J. & Crabtree, G. R. Science 359, eaao5902 (2018).
Liu, P. et al. Angew. Chem. Int. Edn Engl. 53, 10049–10055 (2014).
Zimmermann, M. et al. Angew. Chem. Int. Edn Engl. 53, 4717–4720 (2014).
Gutnick, A., Banghart, M. R., West, E. R. & Schwarz, T. L. Nat. Cell Biol. 21, 768–777 (2019).
Bottone, S. et al. Nat. Methods https://doi.org/10.1038/s41592-023-01988-8 (2023).
Benaissa, H. et al. Nat. Commun. 12, 6989 (2021).
Plamont, M. A. et al. Proc. Natl. Acad. Sci. USA 113, 497–502 (2016).
Tebo, A. G. & Gautier, A. Nat. Commun. 10, 2822 (2019).
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W.W and J.S. are supported by the University of Michigan and National Institutes of Health grant DP2MH132939.
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Wang, W., Shen, J. Fluorogenic chemically induced dimerization. Nat Methods 20, 1454–1455 (2023). https://doi.org/10.1038/s41592-023-01989-7
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DOI: https://doi.org/10.1038/s41592-023-01989-7
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