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Lighting up action potentials with fast and bright voltage sensors

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Three groundbreaking studies have created a new generation of genetically encoded voltage indicators, empowering us to tackle a host of questions on our path toward understanding the brain.

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Fig. 1: Fast voltage sensors to highlight action potentials in neurons, showing fluorescence response to voltage and an example of spikes recording in vivo.

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Acknowledgements

This works is funded by National Institutes of Health (U19NS123719 and U01NS120820 to L.T. and R21EY031858 to L.T. and A.A).

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, USA

    Alessio Andreoni & Lin Tian

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  1. Alessio Andreoni
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  2. Lin Tian
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Correspondence to Lin Tian.

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Competing Interests

L.T. is a co-founder of Seven Biosciences. A.A. declares no competing interests.

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Andreoni, A., Tian, L. Lighting up action potentials with fast and bright voltage sensors. Nat Methods 20, 990–992 (2023). https://doi.org/10.1038/s41592-023-01928-6

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