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Deep brain imaging on the move

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New three-photon miniature microscopes open the study of neuronal networks to those deep in the brains of behaving animals.

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Fig. 1: Single-photon and multiphoton miniature microscopy in freely behaving animals.

References

  1. Zhao et al. Nat. Methods https://doi.org/10.1038/s41592-023-01777-3 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Klioutchnikov, A. et al. Nat. Methods https://doi.org/10.1038/s41592-022-01688-9 (2022).

    Article  PubMed  Google Scholar 

  3. Sofroniew, N. J., Flickinger, D., King, J. & Svoboda, K. eLife 5, e14472 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Rumyantsev, O. I. et al. Nature 580, 100–105 (2020).

    Article  CAS  PubMed  Google Scholar 

  5. Ghosh, K. K. et al. Nat. Methods 8, 871–878 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sawinski, J. et al. Proc. Natl. Acad. Sci. USA 106, 19557–19562 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Zong, W. et al. Nat. Methods 14, 713–719 (2017).

    Article  CAS  PubMed  Google Scholar 

  8. Helmchen, F., Fee, M. S., Tank, D. W. & Denk, W. Neuron 31, 903–912 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Klioutchnikov, A. et al. Nat. Methods 17, 509–513 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. Grewe, B. F. et al. Nature 543, 670–675 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Courtin, J. et al. Science 375, eabg7277 (2022).

    Article  CAS  PubMed  Google Scholar 

  12. Miller, S. M., Marcotulli, D., Shen, A. & Zweifel, L. S. Nat. Neurosci. 22, 565–575 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Gründemann, J. et al. Science 364, eaav8736 (2019).

    Article  PubMed  Google Scholar 

  14. Remedios, R. et al. Nature 550, 388–392 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Li, Y. et al. Cell 171, 1176–1190.e17 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Ziv, Y. et al. Nat. Neurosci. 16, 264–266 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Lecoq, J. & Schnitzer, M. J. Nat. Biotechnol. 29, 715–716 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Takasaki, K., Abbasi-Asl, R. & Waters, J. eNeuro 7, ENEURO.0255-19.2019 (2020).

  19. Zong, W. et al. Cell 185, 1240–1256.e30 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Piyawattanametha, W. et al. Opt. Lett. 34, 2309–2311 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  21. Redman, W. T. et al. eLife 11, e75391 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Zong, W. et al. Nat. Methods 18, 46–49 (2021).

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by the Swiss National Science Foundation (B.F.G., CRSII5-173721 and 315230189251), ETH project funding (B.F.G., ETH-20 19-01), the Human Frontiers Science Program (RGY0072/2019) and funding from the Dr. Wilhelm Hurka Foundation Zurich. We further thank A. Hoffmann for discussions and for helping to acquire the 1P FOV images.

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Correspondence to Jérôme A. Lecoq or Benjamin F. Grewe.

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Lecoq, J.A., Boehringer, R. & Grewe, B.F. Deep brain imaging on the move. Nat Methods 20, 495–496 (2023). https://doi.org/10.1038/s41592-023-01808-z

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