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3D vascularized eye tissue models age-related macular degeneration

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We engineered a 3D outer-blood-retina-barrier (3D-oBRB) with a fully polarized retinal pigment epithelium (RPE) monolayer on top of a Bruch’s membrane and a fenestrated choriocapillaris network. This 3D-oBRB tissue faithfully recapitulates RPE– choriocapillaris interactions, dry age-related macular degeneration (AMD) phenotypes (including sub-RPE drusen deposits and choriocapillaris degeneration) and the wet AMD phenotype of choriocapillaris neovascularization.

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Fig. 1: Modeling type I CNV in 3D-oBRB.

References

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Song, M. J. et al. Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration. Nat. Methods https://doi.org/10.1038/s41592-022-01701-1 (2022).

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3D vascularized eye tissue models age-related macular degeneration. Nat Methods 20, 46–47 (2023). https://doi.org/10.1038/s41592-022-01702-0

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  • DOI: https://doi.org/10.1038/s41592-022-01702-0

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