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Polishing high-quality genome assemblies

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A repeat-aware pipeline corrects structural assembly errors and polishes assembly sequences in large repeats without overcorrection.

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Fig. 1: The polishing strategy to generate CHM13v1.0 and CHM13v1.1 assemblies.

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Acknowledgements

The authors are supported by NIH NIGMS grant GM132713.

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Authors and Affiliations

  1. Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Li Fang & Kai Wang

  2. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Kai Wang

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  1. Li Fang
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  2. Kai Wang
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Correspondence to Kai Wang.

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The authors declare no competing interests.

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Fang, L., Wang, K. Polishing high-quality genome assemblies. Nat Methods 19, 649–650 (2022). https://doi.org/10.1038/s41592-022-01515-1

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