Skip to main content
SpringerLink
Log in

SEQUENCING

Single-cell multiomics to probe relationships between histone modifications and transcription

  • News & Views
  • Published:

From Nature Methods

View current issue Submit your manuscript

Two new technologies enable the profiling of single cells for RNA transcription as well as modifications to histone proteins. Each takes a similar strategy to capture both properties, but with different methods for cell indexing, and they are applied to two different areas: neuroscience and developmental biology, respectively.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Paired-Tag and CoTECH to simultaneously profile histone modifications and transcription in single cells.

References

  1. Zhu, C. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-019-0323-x (2019).

  2. Cao, J. et al. Science 361, 1380–1385 (2018).

    Article  CAS  Google Scholar 

  3. Ma, S. et al. Cell 183, 1103–1116.e20 (2020).

    Article  CAS  Google Scholar 

  4. Zhu, C. et al. Nat. Methods 18, 283–292 (2021).

    Article  CAS  Google Scholar 

  5. Xiong, H., Luo, Y., Wang, Q., Yu, X. & He, A. Nat. Methods https://doi.org/10.1038/s41592-021-01129-z (2021).

  6. Kaya-Okur, H. S. et al. Nat. Commun. 10, 1930 (2019).

    Article  Google Scholar 

  7. Carter, B., Ku, W. L., Tang, Q. & Zhao, K. Nat. Commun. 10, 571208 (2019).

    Article  Google Scholar 

  8. Wang, Q. et al. Mol. Cell 76, 206–216.e7 (2019).

    Article  CAS  Google Scholar 

  9. Domcke, S. et al. Science 370, eaba7612 (2020).

    Article  CAS  Google Scholar 

  10. Stergachis, A. B. et al. Cell 154, 888–903 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular & Medical Genetics, Knight Cardiovascular Institute, Knight Cancer Institute, and Cancer Early Detection Advanced Research Institute, Oregon Health & Science University, Portland, OR, USA

    Andrew C. Adey

Authors
  1. Andrew C. Adey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andrew C. Adey.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Adey, A.C. Single-cell multiomics to probe relationships between histone modifications and transcription. Nat Methods 18, 602–603 (2021). https://doi.org/10.1038/s41592-021-01147-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41592-021-01147-x

  • Springer Nature America, Inc.

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Search

Navigation