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Making a tick protein talk as a serotonin sensor

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23 April 2021 Editor’s Note: The editors of Nature Methods wish to alert readers that the Article “A fast, high-affinity fluorescent serotonin biosensor engineered from a tick lipocalin” by Zhang, S. et al., (Nat Methods 18, 258–261 (2021), doi:10.1038/s41592-021-01078-7) on which this News and Views was based has been retracted. Comments in this News and Views that rely on the accuracy and reproducibility of this data should therefore be reconsidered.

A genetically encoded neurotransmitter sensor, engineered from a tick lipocalin, detects serotonin in the living brain.

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Fig. 1: Genetically encoded serotonin sensors.

Change history

  • 23 April 2021

    Editor’s Note: The editors of Nature Methods wish to alert readers that the Article “A fast, high-affinity fluorescent serotonin biosensor engineered from a tick lipocalin” by Zhang, S. et al., (Nat Methods 18, 258–261 (2021), doi:10.1038/s41592-021-01078-7) on which this News and Views was based has been retracted. Comments in this News and Views that rely on the accuracy and reproducibility of this data should therefore be reconsidered.

References

  1. Gaddum, J. H. in Hypertension: Humoral and Neurogenic Factors (eds Wolstenholme, G.E.W. & Cameron, M.P.) 75–77 (Ciba Foundation Symposium, 1954).

  2. Muller, C. P. & Cunningham, K. A. Handbook of the Behavioral Neurobiology of Serotonin (Academic Press, 2020).

  3. Sabatini, B. L. & Tian, L. Neuron108, 17–32 (2020).

    Article  CAS  Google Scholar 

  4. Zhang, S., Li, X., Zhao, S., Drobizhev, M. & Ai, H.-w. Nat. Methodshttps://doi.org/10.1038/s41592-021-01078-7 (2021).

  5. Wan, J. et al. A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo. Preprint at bioRxivhttps://doi.org/10.1101/2020.02.24.962282 (2020).

  6. Unger, E. K. et al. Cell183, 1986–2002.e1926 (2020).

    Article  CAS  Google Scholar 

  7. Jacobs, B. L. & Fornal, C. A. in Psychopharmacology: The Fourth Generation of Progress (eds Bloom, F. E. & Kupfer, D. J.) 461–469 (Raven, 1995).

  8. Deo, C. et al. Bright and tunable far-red chemogenetic indicators. Preprint at bioRxivhttps://doi.org/10.1101/2020.01.08.898783 (2020).

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Authors and Affiliations

  1. Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK

    Charles W. Morgan & Jing Ren

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  1. Charles W. Morgan
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  2. Jing Ren
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Correspondence to Jing Ren.

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The authors declare no competing interests.

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Morgan, C.W., Ren, J. Making a tick protein talk as a serotonin sensor. Nat Methods 18, 240–241 (2021). https://doi.org/10.1038/s41592-021-01085-8

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