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Neurodegenerative disease

APOE4 homozygosity is a new genetic form of Alzheimer’s disease

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New data confirm that APOE4 homozygosity is a major genetic cause of Alzheimer’s disease, warranting the development of specialized research strategies, treatment approaches and clinical trials.

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Fig. 1: Defining genetic forms of Alzheimer’s disease.

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Acknowledgements

This work is partially supported by grants P01AG073082 and RF1AG076647 to Y.H. from the National Institutes of Health. The authors thank R. Mahley, L. Mucke and J. Blumenfeld for their feedback on the article.

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Authors and Affiliations

  1. Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA

    Qin Xu, Zherui Liang & Yadong Huang

  2. Gladstone Center for Translational Advancement, Gladstone Institutes, San Francisco, CA, USA

    Qin Xu & Yadong Huang

  3. Neuroscience Graduate Program, University of California, San Francisco, CA, USA

    Zherui Liang & Yadong Huang

  4. Departments of Neurology and Pathology, University of California, San Francisco, CA, USA

    Yadong Huang

Authors
  1. Qin Xu
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  2. Zherui Liang
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  3. Yadong Huang
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Corresponding author

Correspondence to Yadong Huang.

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Competing interests

Y.H. is a co-founder and scientific advisory board member of GABAeron, Inc. The other authors declare no competing interests.

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Xu, Q., Liang, Z. & Huang, Y. APOE4 homozygosity is a new genetic form of Alzheimer’s disease. Nat Med 30, 1241–1242 (2024). https://doi.org/10.1038/s41591-024-02923-w

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  • DOI: https://doi.org/10.1038/s41591-024-02923-w

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