Using single-cell RNA and T cell receptor sequencing along with microscopy, we identified the cell types and genes associated with immune checkpoint inhibitor therapy-related colitis. Our study will help to identify targets for early diagnosis and lays the groundwork for the development of safer immunotherapy regimens.
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This is a summary of: Fisher Thomas, M. et al. Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nat. Med. https://doi.org/10.1038/s41591-024-02895-x (2024).
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Studying paired patient tissue and blood enables insights into immunotherapy toxicity. Nat Med 30, 1249–1250 (2024). https://doi.org/10.1038/s41591-024-02900-3
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DOI: https://doi.org/10.1038/s41591-024-02900-3
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