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Cancer therapy

Functional precision medicine for pediatric cancers

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A small, prospective clinical study shows that ex vivo drug screening of pediatric cancer samples can identify effective therapeutic options. If validated, these findings could herald a new approach to precision medicine in this setting.

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Fig. 1: Ex vivo calling of drug hits to support decision making in the clinical treatment of individual children with cancer.

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Authors and Affiliations

  1. Children’s Cancer Institute, Lowy Cancer Centre, UNSW Sydney, Kensington, New South Wales, Australia

    M. Emmy M. Dolman & Paul G. Ekert

  2. UNSW Centre for Childhood Cancer Research, UNSW Sydney, Kensington, New South Wales, Australia

    M. Emmy M. Dolman & Paul G. Ekert

  3. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Melbourne, Victoria, Australia

    Paul G. Ekert

  4. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    Paul G. Ekert

  5. Murdoch Children’s Research Institute, The University of Melbourne Department of Paediatrics, Parkville, Melbourne, Victoria, Australia

    Paul G. Ekert

Authors
  1. M. Emmy M. Dolman
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  2. Paul G. Ekert
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Corresponding authors

Correspondence to M. Emmy M. Dolman or Paul G. Ekert.

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The authors declare no competing interests.

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Dolman, M.E.M., Ekert, P.G. Functional precision medicine for pediatric cancers. Nat Med 30, 940–941 (2024). https://doi.org/10.1038/s41591-024-02863-5

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  • DOI: https://doi.org/10.1038/s41591-024-02863-5

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