We profiled human central nervous system (CNS)-associated macrophages (CAMs) in anatomically dissected CNS interface tissue from typical, fetal and glioblastoma-affected brains using single-cell multi-omics and spatially resolved transcriptomic techniques. Analyses of CAM (and microglia) turnover rates in stem-cell-transplanted glioblastoma and prenatal tissues highlighted the developmental phenotypes of these cells in patients, which lays the groundwork for potential replacement therapies.
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References
Masuda, T. et al. Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature 604, 740–748 (2022). This paper reports the common origin of CAMs and microglia and the postnatal maturation of the brain perivascular space in mice.
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This is a summary of: Sankowski, R. et al. Multiomic spatial landscape of innate immune cells at human central nervous system borders. Nat. Med. https://doi.org/10.1038/s41591-023-02673-1 (2023).
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Human CNS-associated macrophages decoded in time and space. Nat Med 30, 49–50 (2024). https://doi.org/10.1038/s41591-023-02750-5
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DOI: https://doi.org/10.1038/s41591-023-02750-5
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