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The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research

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The All of Us Research Program has prioritized the enrollment of people from backgrounds that are historically under-represented in medical research to bring precision medicine to the full diversity of the US population and to improve health outcomes for all.

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Fig. 1: Prevalence of common health conditions in the USA and among All of Us Research Program participants.

References

  1. Sudlow, C. et al. PLoS Med. 12, e1001779 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Foreman, K. J. et al. Lancet 392, 2052–2090 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Popejoy, A. B. & Fullerton, S. M. Nature 538, 161–164 (2016).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  4. Mills, M. C. & Rahal, C. Nat. Genet. 52, 242–243 (2020).

    Article  CAS  PubMed  Google Scholar 

  5. Martin, A. R. et al. Nat. Genet. 51, 584–591 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Manrai, A. K. et al. N. Engl. J. Med. 375, 655–665 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Denny, J. C. et al. N. Engl. J. Med. 381, 668–676 (2019).

    Article  PubMed  Google Scholar 

  8. Mensah, G. A. et al. Circ. Res. 120, 366–380 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Bargmann, C. I. & Newsome, W. T. JAMA Neurol. 71, 675–676 (2014).

    Article  PubMed  Google Scholar 

  10. GBD 2019 Diseases and Injuries Collaborators. Lancet 396, 1204–1222 (2020).

    Article  Google Scholar 

  11. Baxter, S. L. et al. Am. J. Ophthalmol. 227, 74–86 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Acosta, J. N. et al. J. Am. Heart Assoc. 10, e021724 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Aschebrook-Kilfoy, B. et al. PLOS ONE 17, e0272522 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Lennon, N. J. et al. Preprint at medRxiv https://doi.org/10.1101/2023.05.25.23290535 (2023).

  15. Geck, R. C., Powell, N. R. & Dunham, M. J. Am. J. Hum. Genet. 110, 228–239 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors thank the participants of the All of Us Research Program for their trust, time and contributions.

Author information

Author notes

  1. Patricia Flatley Brennan

    Present address: , Easton, MD, USA

Authors and Affiliations

  1. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Diana W. Bianchi

  2. National Library of Medicine, National Institutes of Health, Bethesda, MD, USA

    Patricia Flatley Brennan

  3. National Eye Institute, National Institutes of Health, Bethesda, MD, USA

    Michael F. Chiang

  4. National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA

    Lindsey A. Criswell

  5. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    Rena N. D’Souza

  6. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Gary H. Gibbons

  7. Clinical Center, National Institutes of Health, Bethesda, MD, USA

    James K. Gilman

  8. National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

    Joshua A. Gordon

  9. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA

    Eric D. Green

  10. Office of Data Science Strategy, National Institutes of Health, Bethesda, MD, USA

    Susan Gregurick

  11. National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

    Richard J. Hodes

  12. Fogarty International Center, National Institutes of Health, Bethesda, MD, USA

    Peter H. Kilmarx

  13. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA

    George F. Koob

  14. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

    Walter J. Koroshetz

  15. National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA

    Helene M. Langevin

  16. National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, USA

    Jon R. Lorsch

  17. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

    Jeanne M. Marrazzo

  18. National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA

    Eliseo J. Pérez-Stable

  19. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    W. Kimryn Rathmell

  20. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

    Griffin P. Rodgers

  21. National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA

    Joni L. Rutter

  22. Offices of the Director and Behavioral and Social Sciences Research, National Institutes of Health, Bethesda, MD, USA

    Jane M. Simoni

  23. National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA

    Bruce J. Tromberg

  24. National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA

    Debara L. Tucci

  25. National Institute of Drug Abuse, National Institutes of Health, Bethesda, MD, USA

    Nora D. Volkow

  26. National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA

    Rick Woychik

  27. National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA

    Shannon N. Zenk

  28. All of Us Research Program, National Institutes of Health, Bethesda, MD, USA

    Elyse Kozlowski, Rachele S. Peterson, Geoffrey S. Ginsburg & Joshua C. Denny

Authors
  1. Diana W. Bianchi
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  2. Patricia Flatley Brennan
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  3. Michael F. Chiang
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  8. Joshua A. Gordon
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  15. Helene M. Langevin
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  18. Eliseo J. Pérez-Stable
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  19. W. Kimryn Rathmell
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  20. Griffin P. Rodgers
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  22. Jane M. Simoni
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  24. Debara L. Tucci
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  26. Rick Woychik
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  27. Shannon N. Zenk
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  28. Elyse Kozlowski
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  29. Rachele S. Peterson
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  30. Geoffrey S. Ginsburg
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  31. Joshua C. Denny
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Corresponding author

Correspondence to Joshua C. Denny.

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The authors declare no competing interests.

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Bianchi, D.W., Brennan, P.F., Chiang, M.F. et al. The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research. Nat Med 30, 330–333 (2024). https://doi.org/10.1038/s41591-023-02744-3

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