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The grand challenge of moving cancer whole-genome sequencing into the clinic

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The largest whole-genome sequencing study thus far has revealed myriad actionable alterations and potential biomarkers for 33 cancer types, but various logistical, technical and economic challenges must be overcome before this technique can become standard of care.

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Fig. 1: WGS versus standard-of-care targeted NGS panels.

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Authors and Affiliations

  1. Department for BioMedical Research, University of Bern, Bern, Switzerland

    Dilara Akhoundova & Mark A. Rubin

  2. Department of Medical Oncology, Inselspital, University Hospital of Bern, Bern, Switzerland

    Dilara Akhoundova

  3. Bern Center for Precision Medicine, Inselspital, University Hospital of Bern, Bern, Switzerland

    Dilara Akhoundova & Mark A. Rubin

Authors
  1. Dilara Akhoundova
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  2. Mark A. Rubin
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Correspondence to Mark A. Rubin.

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The authors declare no competing interests.

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Akhoundova, D., Rubin, M.A. The grand challenge of moving cancer whole-genome sequencing into the clinic. Nat Med 30, 39–40 (2024). https://doi.org/10.1038/s41591-023-02697-7

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