Skip to main content

Advertisement

Log in

A society-wide conversation is needed about germline genome editing using CRISPR

  • Comment
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Therapeutic genome editing has great potential to cure some rare diseases, but germline editing is banned. With a broad societal discussion supported by national and transnational legislation, it could be allowed in certain circumstances.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Doudna, J. A. & Charpentier, E. Science 346, 1258096 (2014).

    Article  PubMed  Google Scholar 

  2. Hsu, P. D. et al. Nat. Biotechnol. 31, 827–832 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Komor, A. C. et al. Nature 533, 420–424 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Anzalone, A. V. et al. Nature 576, 149–157 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Adli, M. Nat. Commun. 9, 1911 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Frangoul, H. et al. N. Engl. J. Med. 384, 252–260 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Kaiser, J. Science https://doi.org/10.1126/science.adf8752 (2022).

    Article  PubMed  Google Scholar 

  8. Musunuru, K. et al. Nature 593, 429–434 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Kolli, N. et al. Int. J. Mol. Sci. 18, 754 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Nagata, K. et al. Nat. Commun. 9, 1800 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Stadtmauer, E. A. et al. Science 367, eaba7365 (2020).

    Article  CAS  PubMed  Google Scholar 

  12. Hu, W. et al. Proc. Natl. Acad. Sci. USA 111, 11461–11466 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Harper, J. C. et al. Eur. J. Hum. Genet. 26, 12–33 (2018).

    Article  CAS  PubMed  Google Scholar 

  14. Callaway, E. Nature 530, 18–18 (2016).

    Article  CAS  PubMed  Google Scholar 

  15. Isasi, R., Kleiderman, E. & Knoppers, B. M. Science 351, 337–339 (2016).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

E.B. thanks V. Hatch for support in producing this Comment.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ewan Birney.

Ethics declarations

Competing interests

E.B. is a paid consultant to Oxford Nanopore and Cantana and a shareholder of Oxford Nanopore.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Birney, E. A society-wide conversation is needed about germline genome editing using CRISPR. Nat Med 30, 30–32 (2024). https://doi.org/10.1038/s41591-023-02681-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-023-02681-1

  • Springer Nature America, Inc.

This article is cited by

Navigation