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Spinal stimulation for unfreezing gait in Parkinson’s disease

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Epidural electrical stimulation of the spinal cord alleviated freezing-of-gait and other postural impairments in a patient with Parkinson’s disease, potentially addressing an unmet need and offering an exciting new avenue for therapy.

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Fig. 1: Lumbar spinal stimulation reduces freezing of gait in advanced PD.

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Authors and Affiliations

  1. Department of Neurology, University of California, San Francisco, CA, USA

    Aviv Mizrahi-Kliger & Karunesh Ganguly

  2. Neurology and Rehabilitation Service, San Francisco VA Health Care System, San Francisco, CA, USA

    Karunesh Ganguly

Authors
  1. Aviv Mizrahi-Kliger
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  2. Karunesh Ganguly
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Corresponding author

Correspondence to Karunesh Ganguly.

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Competing interests

A.M.-K. declares no competing interests. K.G. has a patent (EP3541279B1; US11285321B2) for modulation of sensory inputs to improve motor recovery from stroke, and has been a consultant to Cala Health.

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Mizrahi-Kliger, A., Ganguly, K. Spinal stimulation for unfreezing gait in Parkinson’s disease. Nat Med 29, 2713–2715 (2023). https://doi.org/10.1038/s41591-023-02604-0

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