Aberrant immune responses to the intestinal microbiome have emerged as major contributors to chronic intestinal inflammation, but the microbial species involved in inflammatory bowel diseases remain unknown. Our study identified dietary and commensal yeasts of the gut that drive the expansion of some cross-reactive CD4+ type 1 helper T cells with cytotoxic effector functions, which potentially contributes to immunopathology in patients with Crohn’s disease.
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This is a summary of: Martini, G. R. et al. Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease. Nat. Med. https://doi.org/10.1038/s41591-023-02556-5 (2023).
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Dietary and commensal yeasts drive aberrant T cell responses in Crohn’s disease. Nat Med 29, 2420–2421 (2023). https://doi.org/10.1038/s41591-023-02559-2
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DOI: https://doi.org/10.1038/s41591-023-02559-2
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