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Porcine heart xenotransplantation in brain-dead decedents

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We transplanted gene-edited porcine hearts into two brain-dead human recipients, then evaluated their cardiac function and immune response over the following 66 hours. Both hearts showed sustained cardiac function over the course of the study, without evidence of hyperacute rejection or zoonotic transmission.

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Fig. 1: Study timelines, and cardiac and systemic hemodynamic measurements.

References

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This is a summary of: Moazami, N. et al. Pig-to-human heart xenotransplantation in two recently deceased human recipients. Nat. Med. https://doi.org/10.1038/s41591-023-02471-9 (2023).

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Porcine heart xenotransplantation in brain-dead decedents. Nat Med 29, 1918–1919 (2023). https://doi.org/10.1038/s41591-023-02493-3

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  • DOI: https://doi.org/10.1038/s41591-023-02493-3

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